What is the ideal size of a scale-down model that will allow running multiple bioreactors in a DOE study for cell culture?

What is the ideal size of a scale-down model that will allow running multiple bioreactors in a DOE study for cell culture?

Using the uploaded article and at least one more recent publication (2017 or later), please discuss views on the bioreactor sizing. Briefly mention how the mode of bioreactor operation or the final product, or any other important criterium, could influence the scaling process.
What is the ideal size of a scale-down model that will allow running multiple bioreactors in a DOE study for cell culture?
Consider bioreactor control strategies, labor, raw material cost, sampling, product quality analysis, etc.

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